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Saccharomyces Boulardii: What makes it work as a successful probiotic?

  • Saccharomyces boulardii is a probiotic yeast with proven efficacy in the treatment of gastrointestinal conditions, especially when used as an adjunct to antibiotic treatment.
  • Current data indicates that the benefits of Saccharomyces boulardii appear to be independent of host intestinal colonization, which differentiates its mode of action from other widely used bacterial probiotics.
  • Saccharomyces boulardii binds to pathogens to stop colonization as well as competitive yeast adhesion.
  • Genomic studies have helped identify genome features that confer Saccharomyces boulardii the ability to resist host stress, conferring greater viability through the GI passage than observed for other common probiotics.
  • Saccharomyces boulardii also elicits a complex immunomodulatory effect with roles in fine-tuning immune pathways during pathogen infection or chronic disease.
  • This yeast also contributes to the homeostasis of the normal microbiome and plays a relevant role in the modulation of the secretory functions of intestinal epithelial cells, thus benefiting the nutritional requirements of the host.
  • In general, Saccharomyces boulardii shows a multifactorial role as a probiotic, with proven efficacy and safety in relieving the symptoms of a number of gastrointestinal conditions.

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